Prof. Ruth Ashery-Padan
Principal investigator
Prof. Ruth Ashery-Padan
Principal investigator
Prof. Ruth Ashery-Padan
Principal investigator
Prof. Ruth Ashery-Padan
Principal investigator
Prof. Ruth Ashery-Padan
Principal investigator
Publications
Ovadia S, Cui G, Elkon R, Cohen-Gulkar M, Zuk-Bar N, Tuoc T, et al. SWI/SNF complexes are required for retinal pigmented epithelium differentiation and for the inhibition of cell proliferation and neural differentiation programs. Development. 2023;150(16).
https://pubmed.ncbi.nlm.nih.gov/37522516
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Cohen-Gulkar M, David A, Messika-Gold N, Eshel M, Ovadia S, Zuk-Bar N, et al. The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration. PLoS Biol. 2023;21(1):e3001924. Epub 20230117.
https://pubmed.ncbi.nlm.nih.gov/36649236/
Diacou, R., Nandigrami, P., Fiser, A., Liu, W., Ashery-Padan, R., and Cvekl, A. Cell fate decisions, transcription factors and signaling during early retinal development. Prog Retin Eye Res, 101093 (2022)
https://pubmed.ncbi.nlm.nih.gov/35817658/
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Ashery-Padan, R., Perkins, B.D., and Conte, I. Editorial: With the Eyes on Non-coding RNAs. Front Cell Dev Biol 9, (2021)
https://pubmed.ncbi.nlm.nih.gov/34395454/
Latta, L., Figueiredo, F.C., Ashery-Padan, R., Collinson, J.M., Daniels, J., Ferrari, S., Szentmary, N., Sola, S., Shalom-Feuerstein, R., Lako, M., et al. Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions. Ocul Surf 22, 245-266, (2021)
https://pubmed.ncbi.nlm.nih.gov/34520870/
Pang, J., Le, L., Zhou, Y., Tu, R., Hou, Q., Tsuchiya, D., Thomas, N., Wang, Y., Yu, Z., Alexander, R., et al. NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression. Cell Rep 34, 108603, (2021)
https://pubmed.ncbi.nlm.nih.gov/33440163/
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Menuchin-Lasowski, Y., Dagan, B., Conidi, A., Cohen-Gulkar, M., David, A., Ehrlich, M. et al. Zeb2 regulates the balance between retinal interneurons and muller glia by inhibition of BMP-Smad signaling. Dev Biol, (2020)
http://www.ncbi.nlm.nih.gov/pubmed/32950463
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Lam, P. T., Padula, S. L., Hoang, T. V., Poth, J. E., Liu, L., Liang, C. et al. Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens. Human genomics 13, 10, (2019)
http://www.ncbi.nlm.nih.gov/pubmed/30770771
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Cohen-Tayar, Y., Cohen, H., Mitiagin, Y., Abarbanel, Z., Levy, C., Idelson, M. et al. Pax6 regulation of Sox9 in the retinal pigmented epithelium controls its timely differentiation and choroid vasculature development. Development, (2018)
http://www.ncbi.nlm.nih.gov/pubmed/29986868
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Swisa, A., Avrahami, D., Eden, N., Zhang, J., Feleke, E., Dahan, T. et al. PAX6 maintains beta cell identity by repressing genes of alternative islet cell types. J Clin Invest 127, 230-243, (2017)
http://www.ncbi.nlm.nih.gov/pubmed/27941241
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Remez, L. A., Onishi, A., Menuchin-Lasowski, Y., Biran, A., Blackshaw, S., Wahlin, K. J. et al. Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis. Dev Biol, (2017)
http://www.ncbi.nlm.nih.gov/pubmed/28993200
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Amram, B., Cohen-Tayar, Y., David, A. & Ashery-Padan, R. The retinal pigmented epithelium - from basic developmental biology research to translational approaches. Int J Dev Biol 61, 225-234, (2017)
http://www.ncbi.nlm.nih.gov/pubmed/28621420
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Sun, J., Zhao, Y., McGreal, R., Cohen-Tayar, Y., Rockowitz, S., Wilczek, C. et al. Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers. Epigenetics Chromatin 9, 37 (2016)
http://www.ncbi.nlm.nih.gov/pubmed/27617035
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Naftelberg, S., Abramovitch, Z., Gluska, S., Yannai, S., Joshi, Y., Donyo, M. et al. Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia. PLoS Genet 12, e1006486, (2016)
http://www.ncbi.nlm.nih.gov/pubmed/27997532
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Menuchin-Lasowski, Y., Oren-Giladi, P., Xie, Q., Ezra-Elia, R., Ofri, R., Peled-Hajaj, S. et al. Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals. Development 143, 2829-2841, (2016)
http://www.ncbi.nlm.nih.gov/pubmed/27385012
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He, S., Limi, S., McGreal, R. S., Xie, Q., Brennan, L. A., Kantorow, W. L. et al. Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. Development 143, 1937-1947, (2016)
http://www.ncbi.nlm.nih.gov/pubmed/27246713
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Gueta, K., David, A., Cohen, T., Menuchin-Lasowski, Y., Nobel, H., Narkis, G. et al. The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis. Development, (2016)
http://www.ncbi.nlm.nih.gov/pubmed/27697904
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Bachmann, C., Nguyen, H., Rosenbusch, J., Pham, L., Rabe, T., Patwa, M. et al. mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium. PLoS Genet 12, e1006274, (2016).http://www.ncbi.nlm.nih.gov/pubmed/27611684
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Sun, J., Rockowitz, S., Xie, Q., Ashery-Padan, R., Zheng, D. & Cvekl, A. Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development. Nucleic Acids Res, (2015)
http://www.ncbi.nlm.nih.gov/pubmed/26138486
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Ohana, R., Weiman-Kelman, B., Raviv, S., Tamm, E. R., Pasmanik-Chor, M., Rinon, A. et al. MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors. Development 142, 2487-2498, (2015)
http://www.ncbi.nlm.nih.gov/pubmed/26062936
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Carpenter, A. C., Smith, A. N., Wagner, H., Cohen-Tayar, Y., Rao, S., Wallace, V. et al. Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse. Development 142, 972-982, (2015)
http://www.ncbi.nlm.nih.gov/pubmed/25715397
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Raviv, S., Bharti, K., Rencus-Lazar, S., Cohen-Tayar, Y., Schyr, R., Evantal, N. et al. PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF. PLoS Genet 10, e1004360, (2014)
http://www.ncbi.nlm.nih.gov/pubmed/24875170
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Dvashi, Z., Shalom, H. J., Shohat, M., Ben-Meir, D., Ferber, S., Satchi-Fainaro, R. et al. Protein Phosphatase Magnesium Dependent 1A Governs the Wound Healing-Inflammation-Angiogenesis Cross Talk on Injury. Am J Pathol, (2014)
http://www.ncbi.nlm.nih.gov/pubmed/25196308
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David, A., Liu, F., Tibelius, A., Vulprecht, J., Wald, D., Rothermel, U. et al. Lack of centrioles and primary cilia in STIL(-/-) mouse embryos. Cell Cycle 13, 2859-2868, (2014)
http://www.ncbi.nlm.nih.gov/pubmed/25486474
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Cvekl, A. & Ashery-Padan, R. The cellular and molecular mechanisms of vertebrate lens development. Development 141, 4432-4447, (2014)
http://www.ncbi.nlm.nih.gov/pubmed/25406393
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Benavente, C. A., Finkelstein, D., Johnson, D. A., Marine, J. C., Ashery-Padan, R. & Dyer, M. A. Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression. Oncotarget, (2014)
http://www.ncbi.nlm.nih.gov/pubmed/25338120
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Zembrzycki, A., Chou, S. J., Ashery-Padan, R., Stoykova, A. & O'Leary, D. D. Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits. Nat Neurosci 16, 1060-1067, (2013)
http://www.ncbi.nlm.nih.gov/pubmed/23831966
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Wolf, L., Harrison, W., Huang, J., Xie, Q., Xiao, N., Sun, J. et al. Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res, (2013)
http://www.ncbi.nlm.nih.gov/pubmed/24038357
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Wolf, L., Gao, C. S., Gueta, K., Xie, Q., Chevallier, T., Podduturi, N. R. et al. Identification and Characterization of FGF2-Dependent mRNA:microRNA Networks During Lens Fiber Cell Differentiation. G3 (Bethesda), (2013)
http://www.ncbi.nlm.nih.gov/pubmed/24142921
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Shaham, O., Gueta, K., Mor, E., Oren-Giladi, P., Grinberg, D., Xie, Q. et al. Pax6 Regulates Gene Expression in the Vertebrate Lens through miR-204. PLoS Genet 9, e1003357, (2013)
http://www.ncbi.nlm.nih.gov/pubmed/23516376
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Farhy, C., Elgart, M., Shapira, Z., Oron-Karni, V., Yaron, O., Menuchin, Y. et al. Pax6 is required for normal cell-cycle exit and the differentiation kinetics of retinal progenitor cells. PLoS One 8, e76489, (2013)
http://www.ncbi.nlm.nih.gov/pubmed/24073291
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Bochner, R., Ziv, Y., Zeevi, D., Donyo, M., Abraham, L., Ashery-Padan, R. et al. Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model. Hum Mol Genet, (2013)
http://www.ncbi.nlm.nih.gov/pubmed/23515154
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Shaham, O., Menuchin, Y., Farhy, C. & Ashery-Padan, R. Pax6: a multi-level regulator of ocular development. Prog Retin Eye Res 31, 351-376, (2012).
http://www.ncbi.nlm.nih.gov/pubmed/22561546
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Magenheim, J., Klein, A. M., Stanger, B. Z., Ashery-Padan, R., Sosa-Pineda, B., Gu, G. et al. Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. Dev Biol 359, 26-36, (2011)
http://www.ncbi.nlm.nih.gov/pubmed/21888903
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Huang, J., Rajagopal, R., Liu, Y., Dattilo, L. K., Shaham, O., Ashery-Padan, R. et al. The mechanism of lens placode formation: a case of matrix-mediated morphogenesis. Dev Biol 355, 32-42, (2011)
http://www.ncbi.nlm.nih.gov/pubmed/21540023
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Davis, N., Mor, E. & Ashery-Padan, R. Roles for Dicer1 in the patterning and differentiation of the optic cup neuroepithelium. Development 138, 127-138, (2011)
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Kroeber, M., Davis, N., Holzmann, S., Kritzenberger, M., Shelah-Goraly, M., Ofri, R. et al. Reduced expression of Pax6 in lens and cornea of mutant mice leads to failure of chamber angle development and juvenile glaucoma. Hum Mol Genet, (2010)
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He, S., Pirity, M. K., Wang, W. L., Wolf, L., Chauhan, B. K., Cveklova, K. et al. Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin 3, 21, (2010)
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Bandah-Rozenfeld, D., Mizrahi-Meissonnier, L., Farhy, C., Obolensky, A., Chowers, I., Pe'er, J. et al. Homozygosity mapping reveals null mutations in FAM161A as a cause of autosomal-recessive retinitis pigmentosa. Am J Hum Genet 87, 382-391, (2010)
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Tuoc, T. C., Radyushkin, K., Tonchev, A. B., Pinon, M. C., Ashery-Padan, R., Molnar, Z. et al. Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice. J Neurosci 29, 8335-8349, (2009)
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Smith, A. N., Miller, L. A., Radice, G., Ashery-Padan, R. & Lang, R. A. Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis. Development 136, 2977-2985, (2009)
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Shaham, O., Smith, A. N., Robinson, M. L., Taketo, M. M., Lang, R. A. & Ashery-Padan, R. Pax6 is essential for lens fiber cell differentiation. Development 136, 2567-2578, (2009)
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Davis, N., Yoffe, C., Raviv, S., Antes, R., Berger, J., Holzmann, S. et al. Pax6 dosage requirements in iris and ciliary body differentiation. Dev Biol 333, 132-142, (2009)
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Boretius, S., Michaelis, T., Tammer, R., Ashery-Padan, R., Frahm, J. & Stoykova, A. In vivo MRI of altered brain anatomy and fiber connectivity in adult pax6 deficient mice. Cereb Cortex 19, 2838-2847, (2009)
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Baranes, K., Raz-Prag, D., Nitzan, A., Galron, R., Ashery-Padan, R., Rotenstreich, Y. et al. Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system. Exp Neurol 218, 24-32, (2009)
http://www.ncbi.nlm.nih.gov/pubmed/19345213
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Pontoriero, G. F., Deschamps, P., Ashery-Padan, R., Wong, R., Yang, Y., Zavadil, J. et al. Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype. Dev Dyn 237, 602-617, (2008)
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Pinon, M. C., Tuoc, T. C., Ashery-Padan, R., Molnar, Z. & Stoykova, A. Altered molecular regionalization and normal thalamocortical connections in cortex-specific Pax6 knock-out mice. J Neurosci 28, 8724-8734, (2008)
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Oron-Karni, V., Farhy, C., Elgart, M., Marquardt, T., Remizova, L., Yaron, O. et al. Dual requirement for Pax6 in retinal progenitor cells. Development 135, 4037-4047, (2008)
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Davis-Silberman, N. & Ashery-Padan, R. Iris development in vertebrates; genetic and molecular considerations. Brain Res 1192, 17-28, (2008)
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Brill, M. S., Snapyan, M., Wohlfrom, H., Ninkovic, J., Jawerka, M., Mastick, G. S. et al. A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb. J Neurosci 28, 6439-6452, (2008)
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Xu, S., Sunderland, M. E., Coles, B. L., Kam, A., Holowacz, T., Ashery-Padan, R. et al. The proliferation and expansion of retinal stem cells require functional Pax6. Dev Biol 304, 713-721, (2007)
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Swamynathan, S. K., Katz, J. P., Kaestner, K. H., Ashery-Padan, R., Crawford, M. A. & Piatigorsky, J. Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol 27, 182-194, (2007)
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Strom, A., Bonal, C., Ashery-Padan, R., Hashimoto, N., Campos, M. L., Trumpp, A. et al. Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134, 2719-2725, (2007)
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Finkler, A., Ashery-Padan, R. & Fromm, H. CAMTAs: Calmodulin-binding transcription activators from plants to human. FEBS Lett 581, 3893-3898, (2007)
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Bumsted-O'Brien, K. M., Hendrickson, A., Haverkamp, S., Ashery-Padan, R. & Schulte, D. Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina. J Comp Neurol 505, 58-72, (2007)
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Alberstein, M., Amit, M., Vaknin, K., O'Donnell, A., Farhy, C., Lerenthal, Y. et al. Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing. Rna, (2007)
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Yaron, O., Farhy, C., Marquardt, T., Applebury, M. & Ashery-Padan, R. Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina. Development 133, 1367-1378, (2006)
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Hack, M. A., Saghatelyan, A., de Chevigny, A., Pfeifer, A., Ashery-Padan, R., Lledo, P. M. et al. Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat Neurosci 8, 865-872, (2005)
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Garcia, C. M., Yu, K., Zhao, H., Ashery-Padan, R., Ornitz, D. M., Robinson, M. L. et al. Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation. Dev Dyn 233, 516-527, (2005)
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Dwivedi, D. J., Pontoriero, G. F., Ashery-Padan, R., Sullivan, S., Williams, T. & West-Mays, J. A. Targeted Deletion of AP-2{alpha} Leads to Disruption in Corneal Epithelial Cell Integrity and Defects in the Corneal Stroma. Invest Ophthalmol Vis Sci 46, 3623-3630, (2005)
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Davis-Silberman, N., Kalich, T., Oron-Karni, V., Marquardt, T., Kroeber, M., Tamm, E. R. et al. Genetic dissection of Pax6 dosage requirements in the developing mouse eye. Hum Mol Genet 14, 2265-2276, (2005)
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Beebe, D., Garcia, C., Wang, X., Rajagopal, R., Feldmeier, M., Kim, J. Y. et al. Contributions by members of the TGFbeta superfamily to lens development. Int J Dev Biol 48, 845-856, (2004)
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Ashery-Padan, R., Zhou, X., Marquardt, T., Herrera, P., Toube, L., Berry, A. et al. Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. Dev Biol 269, 479-488, (2004)
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Ahituv, N., Erven, A., Fuchs, H., Guy, K., Ashery-Padan, R., Williams, T. et al. An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm Genome 15, 424-432, (2004)
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Baumer, N., Marquardt, T., Stoykova, A., Spieler, D., Treichel, D., Ashery-Padan, R. et al. Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development 130, 2903-2915, (2003)
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Baumer, N., Marquardt, T., Stoykova, A., Ashery-Padan, R., Chowdhury, K. & Gruss, P. Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle. Development 129, 4535-4545, (2002)
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Ashery-Padan, R. Somatic gene targeting in the developing and adult mouse retina. Methods 28, 457-464, (2002)
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Schaft, J., Ashery-Padan, R., van der Hoeven, F., Gruss, P. & Stewart, A. F. Efficient FLP recombination in mouse ES cells and oocytes. Genesis 31, 6-10, (2001)
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Marquardt, T., Ashery-Padan, R., Andrejewski, N., Scardigli, R., Guillemot, F. & Gruss, P. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105, 43-55, (2001)
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Ashery-Padan, R. & Gruss, P. Pax6 lights-up the way for eye development. Curr Opin Cell Biol 13, 706-714, (2001)
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Ashery-Padan, R., Marquardt, T., Zhou, X. & Gruss, P. Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev 14, 2701-2711, (2000)
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Ashery-Padan, R., Alvarez-Bolado, G., Klamt, B., Gessler, M. & Gruss, P. Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain. Mech Dev 80, 213-217, (1999)
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Goldberg, M., Lu, H., Stuurman, N., Ashery-Padan, R., Weiss, A. M., Yu, J. et al. Interactions among Drosophila nuclear envelope proteins lamin, otefin, and YA. Mol Cell Biol 18, 4315-4323, (1998)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9632815
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Ashery-Padan, R., Weiss, A. M., Feinstein, N. & Gruenbaum, Y. Distinct regions specify the targeting of otefin to the nucleoplasmic side of the nuclear envelope. J Biol Chem 272, 2493-2499, (1997)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8999964
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Ashery-Padan, R., Ulitzur, N., Arbel, A., Goldberg, M., Weiss, A. M., Maus, N. et al. Localization and posttranslational modifications of otefin, a protein required for vesicle attachment to chromatin, during Drosophila melanogaster development. Mol Cell Biol 17, 4114-4123, (1997)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9199347
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Padan, R., Nainudel-Epszteyn, S., Goitein, R., Fainsod, A. & Gruenbaum, Y. Isolation and characterization of the Drosophila nuclear envelope otefin cDNA. J Biol Chem 265, 7808-7813, (1990)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2186029
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Neville, L. F., Gnatt, A., Padan, R., Seidman, S. & Soreq, H. Anionic site interactions in human butyrylcholinesterase disrupted by two single point mutations. J Biol Chem 265, 20735-20738, (1990)
